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영남의대학술지 Vol.28 No.1 p77-83, June2011
Case Report
전이성 혈관주위세포종 환자에서 발생한 저혈당을 프레드니솔론으로 치료한 1예
Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy
박성우, 김동근, 김명진, 장효진, 손세훈, 고성애, 이하영, 김민경, 이경희, 현명수
영남대학교 의과대학 내과학교실
교신저자：현명수, 대구광역시 남구 대명5동 317-1, 영남대학교 의과대학 내과학교실
Tel: (053) 620-3837, Fax: (053) 654- 8386
E-mail : hms@med.yu.ac.kr
June 30, 2011
Abstract
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non- islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF II). Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of ‘big’-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.
Key Words: Hemangiopericytoma, Hypoglycemia, Prednisolone
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